30872466), National Program on Key Basic Research Project (973 Program) of China (to ZM, No. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedĭata Availability: All relevant data are within the paper.įunding: This work was supported by National Natural Science Foundation of China (to ZM, No. Received: MaAccepted: JPublished: August 18, 2015Ĭopyright: © 2015 Zhi et al. PLoS ONE 10(8):Įditor: Giuseppe Pirozzi, Istituto Nazionale Tumori, ITALY

(2015) B7H1 Expression and Epithelial-To-Mesenchymal Transition Phenotypes on Colorectal Cancer Stem-Like Cells. B7H1 expression and EMT phenotypes on CSCs indicates a possible immunoevasion way.Ĭitation: Zhi Y, Mou Z, Chen J, He Y, Dong H, Fu X, et al. Furthermore, some B7H1 + cancer cells also showed the characteristic of EMT, indicating EMT cells could escape immune attack during metastasis. Moreover, CD133 + cells in both cell line and colorectal cancer tissues expressed high level of negative co-stimulate molecule B7H1. These CD133 + cells possess EMT gene expression profile including higher level of Snail, Twist, vimentin, fibronectin and lower level of E-cadherin. We enriched CD133 + colorectal cancer cells which manifested the CSCs-like properties such as higher levels of other stem cell markers Oct-4 and Sox-2, tumor sphere forming ability and more tumorigenic in NOD/SCID mice. Therefore, we determined the expression of B7H1 and EMT-associated markers in colorectal cancer stem-like cells to investigate a possible immunoevasion way of CSCs. B7H1 is crucial negative co-stimulatory molecule but little information about whether it works in CSCs. However, how they escape immune surveillance is unclear. Cancer stem cells (CSCs) can invade and metastasize by epithelial-to-mesenchymal transition (EMT).

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